In Vitro Matured Human Pluripotent Stem Cell-Derived Cardiomyocytes Form Grafts With Enhanced Structure and Function in Injured Hearts.

Wahiba DhahriTamilla Sadikov ValdmanDan WilkinsonElizabeth PereiraEylül CeylanNaaz AndhariaBeiping QiangHassan MasoudpourFanny WulkanElya QuesnelWenlei JiangShunsuke FunakoshiAmine MazineM Juliana Gomez-GarciaNeda LatifiYidi JiangElla HusztiCraig A SimmonsGordon KellerMichael A Laflamme

Published in: Circulation (2022)

We describe practical methods for the scaled generation of mature hPSC-CMs and provide the first evidence that the transplantation of more mature cardiomyocytes yields better outcomes in vivo.

Keyphrases

endothelial cells
high glucose
induced pluripotent stem cells
pluripotent stem cells
stem cells
bone marrow
insulin resistance