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MicroRNA-325-3p protects the heart after myocardial infarction by inhibiting RIPK3 and programmed necrosis in mice.

Dong-Ying ZhangBing-Jian WangMin MaKun YuQing ZhangXi-Wen Zhang
Published in: BMC molecular biology (2019)
The RIPK1/RIPK3/p-MLKL axis-induced necroptosis that occurred during MI was mediated by a miRNA module, miR-325-3p, which can effectively ameliorate the symptoms of MI by suppressing the expression of RIPK3.
Keyphrases
  • poor prognosis
  • heart failure
  • high glucose
  • signaling pathway
  • type diabetes
  • drug induced
  • high fat diet induced
  • oxidative stress
  • insulin resistance
  • endothelial cells