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Small GTP-binding protein Rap1 mediates EGF and HB-EGF signaling and modulates EGF receptor expression in HTR-8/SVneo extravillous trophoblast cells.

Mikihiro YoshieKensuke OhishiGen IshikawaAtsuya TsuruKazuya KusamaMana AzumiKazuhiro Tamura
Published in: Reproductive medicine and biology (2023)
Rap1 may function as a mediator of EGF and HB-EGF signaling pathways and can modulate EGFR expression in EVTs during placental development.
Keyphrases
  • growth factor
  • binding protein
  • induced apoptosis
  • small cell lung cancer
  • signaling pathway
  • poor prognosis
  • cell cycle arrest
  • epithelial mesenchymal transition
  • pi k akt
  • endoplasmic reticulum stress