ALK Inhibitors in Patients With ALK Fusion-Positive GI Cancers: An International Data Set and a Molecular Case Series.
Margherita AmbrosiniMarzia Del ReFrancesco PantanoAndrew E HendifarAlexander E DrilonGuilherme HaradaAnne Hansen ReeSamuel J KlempnerGunhild Mari MælandsmoNorman John CarrHege G RussnesJames M ClearyHarshabad SinghElisa SottotettiAntonia MartinettiGiovanni RandonAndrea Sartore-BianchiIolanda CaponeMassimo MilioneMaria Di BartolomeoFilippo PietrantonioPublished in: JCO precision oncology (2022)
rearrangements represent an important therapeutic target in individual pretreated patients with GI solid tumors. Further work providing prospective clinical validation of this target is needed.