A diagnostic accuracy study to evaluate standard rapid diagnostic test (RDT) alone to safely rule out imported malaria in children presenting to UK emergency departments.

Chris BirdGail N HaywardPhilip J TurnerVanessa MerrickMark D LyttleNiall MullenThomas R Fanshawenull null

Published in: Journal of the Pediatric Infectious Diseases Society (2023)

RDTs were 100% sensitive in detecting P. falciparum malaria. However, lower sensitivity for other malaria species and the rise of pfhrp2 and pfhrp3 (pfhrp2/3) gene deletions in the P. falciparum parasite mandate the continued use of microscopy for diagnosing malaria.

Keyphrases

plasmodium falciparum
high resolution
cross sectional
copy number
dna methylation
single molecule
case report
high throughput
high speed
gene expression
mass spectrometry
quantum dots
sensitive detection