Prolotherapy for knee osteoarthritis using hypertonic dextrose vs other interventional treatments: systematic review of clinical trials.
Pedro Iván Arias-VázquezCarlos Alfonso Tovilla-ZárateBlanca Gabriela Legorreta-RamírezWajid Burad FonzDory Magaña-RicardezThelma Beatriz González-CastroIsela Esther Juárez-RojopMaría Lilia López-NarváezPublished in: Advances in rheumatology (London, England) (2019)
In terms of pain reduction and function improvement, prolotherapy with hypertonic dextrose was more effective than infiltrations with local anesthetics, as effective as infiltrations with hyaluronic acid, ozone or radiofrequency and less effective than PRP and erythropoietin, with beneficial effect in the short, medium and long term. In addition, no side effects or serious adverse reactions were reported in patients treated with hypertonic dextrose. Although HDP seems to be a promising interventional treatment for knee OA, more studies with better methodological quality and low risk of bias are needed to confirm the efficacy and safety of this intervention.
Keyphrases
- knee osteoarthritis
- hyaluronic acid
- systematic review
- clinical trial
- randomized controlled trial
- chronic pain
- meta analyses
- total knee arthroplasty
- emergency department
- pain management
- particulate matter
- hydrogen peroxide
- spinal cord injury
- spinal cord
- nitric oxide
- atrial fibrillation
- quality improvement
- catheter ablation
- recombinant human
- smoking cessation
- replacement therapy
- double blind
- drug induced