Anticoagulation in the management of neonatal cerebral sinovenous thrombosis: a systematic review and meta-analysis.
Thomas RossorTomoki ArichiSanjay BhateAnthony Richard HartRahul Raman SinghPublished in: Developmental medicine and child neurology (2018)
No randomized studies have evaluated anticoagulation therapy (ACT) in neonatal cerebral sinovenous thrombosis. ACT may reduce thrombus propagation. No evidence of increased morbidity or mortality with ACT was demonstrated. A position of equipoise is justified, supporting the need for placebo-controlled randomized trials.
Keyphrases
- placebo controlled
- double blind
- pulmonary embolism
- atrial fibrillation
- subarachnoid hemorrhage
- venous thromboembolism
- phase iii
- phase ii
- open label
- clinical trial
- study protocol
- cardiovascular events
- cerebral ischemia
- phase ii study
- brain injury
- risk factors
- randomized controlled trial
- blood brain barrier
- smoking cessation