Soat2 ties cholesterol metabolism to β-oxidation and glucose tolerance in male mice.

Camilla PramfalkOsman AhmedMatteo PedrelliMirko E MinnitiSerge LuquetRaphaël Gp DenisMaria OlinJennifer HärdfeldtLise-Lotte VedinKnut R SteffensenMikael RydénLeanne HodsonMats ErikssonPaolo Parini

Published in: Journal of internal medicine (2022)

Our data demonstrate that ACAT2-generated cholesteryl esters negatively affect the metabolic control by retaining TG in the liver and that genetic inhibition of Soat2 improves liver steatosis via partitioning of lipids into secretory (VLDL-TG) and oxidative (fatty acids) pathways.

Keyphrases

fatty acid
insulin resistance
high fat diet
electronic health record
genome wide
hydrogen peroxide
big data
copy number
type diabetes
low density lipoprotein
gene expression
dna methylation
high fat diet induced
artificial intelligence
electron transfer