Fluorescent-guided surgery for sentinel lymph node detection in gastric cancer and carcinoembryonic antigen targeted fluorescent-guided surgery in colorectal and pancreatic cancer.
Floris A VuijkDenise E HillingJ Sven D MieogAlexander L VahrmeijerPublished in: Journal of surgical oncology (2018)
Sentinel lymph node procedures for gastric cancer resections using indocyanine green (ICG) linked to Nanocoll outperformed normal ICG but did not provide information on possible lymph node metastasis. Carcinoembryonic antigen targeted fluorescent imaging using SGM-101 was successful in both pancreatic and colorectal cancer. A large phase III multicentre trial will soon be initiated in colorectal cancer patients.
Keyphrases
- sentinel lymph node
- phase iii
- lymph node metastasis
- quantum dots
- clinical trial
- label free
- early stage
- lymph node
- minimally invasive
- neoadjuvant chemotherapy
- open label
- coronary artery bypass
- living cells
- fluorescence imaging
- double blind
- phase ii
- study protocol
- squamous cell carcinoma
- cancer therapy
- surgical site infection
- placebo controlled
- high resolution
- papillary thyroid
- fluorescent probe
- randomized controlled trial
- photodynamic therapy
- healthcare
- sensitive detection
- percutaneous coronary intervention
- liver metastases
- locally advanced