Deprived social status is associated with decreased use of oral chemotherapy in patients with metastatic colorectal cancer: A retrospective cohort study on administrative databases in a French University Hospital.
Gwendoline GautierMélodie LucasThomas VermeulinFrederic Di FioreVeronique MerlePublished in: Pharmacology research & perspectives (2022)
Factors associated with the choice of oral versus intravenous CT are not clearly established. Our purpose was to evaluate the influence of social status and home distance to hospital on the use of oral CT in patients with metastatic colorectal cancer (mCRC). This retrospective single-center study included mCRC patients between 2011 and 2017. Patient social status was assessed by European Deprivation Index (EDI) and home distance to the hospital was calculated. Univariable and multivariable logistic regression analyses were performed. One hundred and seventy-five mCRC patients were included, with 71 receiving oral CT. Most deprived patients received less oral CT (OR 0.5 [0.26, 0.96], p = .039). No association was found for road distance. Previous use of adjuvant oral CT was associated with oral CT in mCRC (OR 2.65 [1.06, 6.66], p = .038). Our results suggest that deprived social status is a factor associated with decreased use of oral CT in patients with mCRC. Clinical trial registration: no registration.
Keyphrases
- healthcare
- image quality
- computed tomography
- end stage renal disease
- dual energy
- contrast enhanced
- clinical trial
- ejection fraction
- newly diagnosed
- metastatic colorectal cancer
- chronic kidney disease
- mental health
- prognostic factors
- magnetic resonance imaging
- peritoneal dialysis
- randomized controlled trial
- radiation therapy
- open label
- machine learning
- patient reported outcomes
- low dose
- decision making
- big data
- locally advanced
- pet ct