Dynamic contrast-enhanced MRI predicts PTEN protein expression which can function as a prognostic measure of progression-free survival in NPC patients.
Gang WuWeiyuan HuangJunnv XuWenzhu LiYu WuQianyu YangKun LiuMingyue ZhuPriya S BalasubramanianMengsen LiPublished in: Journal of cancer research and clinical oncology (2021)
PTEN negative indicated a shorter PFS and worse prognosis than PTEN positive in NPC patients. Ktrans and Kep derived from DCE-MRI, which yielded reliable capability, may be considered as potential imaging markers that are correlated with PTEN expression and could be used to predict PTEN expression noninvasively. Combined radiological and clinical features can improve the performance of the classification of PTEN expression.
Keyphrases
- cell proliferation
- pi k akt
- end stage renal disease
- poor prognosis
- ejection fraction
- newly diagnosed
- free survival
- magnetic resonance imaging
- chronic kidney disease
- machine learning
- computed tomography
- high resolution
- prognostic factors
- magnetic resonance
- binding protein
- risk assessment
- diffusion weighted imaging
- climate change
- human health