A Novel Human Interleukin-23A Overexpressing Mouse Model of Systemic Lupus Erythematosus.

Eleni Christodoulou-VafeiadouChristina GekaLida IliopoulouLydia NtariMaria C DenisNiki KaragianniGeorge Kollias

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2024)

We have generated and characterized a novel genetic mouse model of SLE, providing proof-of-concept for the etiopathogenic role of human IL-23A. This new model has a normal life span and integrates several characteristics of the human disease's complexity and chronicity, making it an attractive preclinical tool for studying IL-23-dependent pathogenic mechanisms and assessing the efficacy of anti-human IL-23A or modeled disease-related therapeutics.

Keyphrases

endothelial cells
systemic lupus erythematosus
mouse model
induced pluripotent stem cells
pluripotent stem cells
rheumatoid arthritis
dna methylation
bone marrow
mesenchymal stem cells