Protective Effect of Baicalin on Chlorpyrifos-Induced Liver Injury and Its Mechanism.
Ruibing WangKe ZhangKaiyue LiuHongyan PeiKun ShiZhongmei HeYing ZongRui DuPublished in: Molecules (Basel, Switzerland) (2023)
Chlorpyrifos (CPF) plays a vital role in the control of various pests in agriculture and household life, even though some studies have indicated that CPF residues pose a significant risk to human health. Baicalin (BA) is a flavonoid drug with an obvious effect on the prevention and treatment of liver diseases. In this study, the protective effect of BA in vitro and in vivo was investigated by establishing a CPF-induced AML12 cell damage model and a CPF-induced Kunming female mouse liver injury model. The AML12 cell damage model indicated that BA had a good positive regulatory effect on various inflammatory factors, redox indexes, and abnormal apoptosis factors induced by CPF. The liver injury model of female mice in Kunming showed that BA significantly improved the liver function indexes, inflammatory response, and fibrosis of mice. In addition, BA alleviated CPF-induced AML12 cell damage and Kunming female mouse liver injury by enhancing autophagy and regulating apoptosis pathways through Western blotting. Collectively, these data suggest that the potential mechanism of BA is a multi-target and multi-channel treatment for chlorpyrifos-induced liver injury.
Keyphrases
- drug induced
- liver injury
- oxidative stress
- genome editing
- diabetic rats
- human health
- crispr cas
- single cell
- acute myeloid leukemia
- inflammatory response
- high glucose
- endoplasmic reticulum stress
- risk assessment
- cell death
- cell therapy
- climate change
- type diabetes
- adverse drug
- south africa
- cell cycle arrest
- cell proliferation
- mesenchymal stem cells
- big data
- deep learning
- emergency department
- artificial intelligence
- acute lymphoblastic leukemia
- insulin resistance
- replacement therapy
- pi k akt