Mineral trioxide aggregate suppresses pro-inflammatory cytokine expression via the calcineurin/nuclear factor of activated T cells/early growth response 2 pathway in lipopolysaccharide-stimulated macrophages.

M Kuramoto Nobuyuki Kawashima K Tazawa K Nara M Fujii Sonoko Noda Kentaro Hashimoto Kosuke Nozaki Takashi Okiji

Published in: International endodontic journal (2020)

Mineral trioxide aggregate extracts induced downregulation of IL-1α and IL-6 in LPS-stimulated RAW264.7 cells via CaSR-induced activation of calcineurin/NFAT/Egr2 signalling and subsequent upregulation of IL-10 and Socs3.

Keyphrases

nuclear factor
toll like receptor
poor prognosis
signaling pathway
high glucose
diabetic rats
inflammatory response
induced apoptosis
cell cycle arrest
oxidative stress
long non coding rna
anti inflammatory
cell death
endoplasmic reticulum stress
pi k akt