Clarithromycin attenuates the expression of monocyte chemoattractant protein-1 by activating toll-like receptor 4 in human mesangial cells.
Koji TsugawaTadaatsu ImaizumiShojiro WatanabeKazushi TsurugaHidemi YoshidaHiroshi TanakaPublished in: Clinical and experimental nephrology (2016)
Our results indicated that CAM exerted renoprotective effects by suppression of p38 MAPK activity and by decreasing the expression of MCP-1 in LPS-stimulated MCs. Given the implication of TLR4 signaling in CKD, CAM may be a potential treatment of choice for CKD.
Keyphrases
- toll like receptor
- inflammatory response
- poor prognosis
- endothelial cells
- nuclear factor
- chronic kidney disease
- immune response
- binding protein
- induced apoptosis
- helicobacter pylori
- diabetic nephropathy
- signaling pathway
- dendritic cells
- cell cycle arrest
- long non coding rna
- helicobacter pylori infection
- anti inflammatory
- high glucose
- amino acid
- cell death
- risk assessment
- replacement therapy