Antidiabetic E4orf1 protein prevents hepatic steatosis and reduces markers of aging-related cellular damage in high fat fed older mice.
Zahra MostofinejadMd AkheruzzamanMd Abu Bakkar SiddikPresheet PatkarNikhil V DhurandharVijay K HegdePublished in: BMJ open diabetes research & care (2021)
E4orf1 has the potential to improve glycemic control in older mice, and the improvement persists even after longer term exposure. E4orf1 expression also maintains mitochondrial integrity and telomere attrition, thus delaying age-associated diseases. This provides strong evidence for therapeutic utility of E4orf1 in improving age-associated metabolic and cellular changes that occur with aging in humans.
Keyphrases
- glycemic control
- type diabetes
- oxidative stress
- high fat diet induced
- physical activity
- community dwelling
- poor prognosis
- middle aged
- preterm infants
- binding protein
- insulin resistance
- weight loss
- mouse model
- risk assessment
- metabolic syndrome
- small molecule
- wild type
- long non coding rna
- human health
- drug induced
- amino acid