Steroids Inhibit Eosinophil Accumulation and Downregulate Hematopoietic Chemotaxic Prostaglandin D2 Receptor in Aspirin-Exacerbated Respiratory Disease.
Norio SuzukiElizabeth P Ko-MitamuraTakaki InuiTetsuya TeradaKenji DejimaNanae NagataYoshihiro UradeRyo KawataPublished in: Ear, nose, & throat journal (2020)
This study provides clear evidence that systemic steroid therapy inhibits eosinophil activation and decreases HPGDS and DP2 expression in patients with AERD, indicating a reduction in prostaglandin D2 production and hence control hyperplasia of nasal polyps.