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Demographic history and genetic structure in pre-Hispanic Central Mexico.

Viridiana Villa-IslasAlan Izarraras-GomezMaximilian LarenaElizabeth Mejía Perez CamposMarcela Sandoval VelascoJuan Esteban Rodríguez-RodríguezMiriam J Bravo-LopezBarbara MoguelRosa Irene Fregel LorenzoErnesto Garfias-MoralesJazeps Medina TretmanisDavid Alberto Velázquez-RamírezAlberto Herrera-MuñózKarla SandovalMaria A Nieves-ColónGabriela Zepeda García MorenoFernando A VillaneaEugenia Fernández Villanueva MedinaRamiro Aguayo-HaroCristina ValdioseraAlexander G IoannidisAndrés Moreno-EstradaFlora JayEmilia Huerta-SánchezJ Víctor Moreno-MayarFederico Sánchez QuintoMaría C Ávila Arcos
Published in: Science (New York, N.Y.) (2023)
Aridoamerica and Mesoamerica are two distinct cultural areas in northern and central Mexico, respectively, that hosted numerous pre-Hispanic civilizations between 2500 BCE and 1521 CE. The division between these regions shifted southward because of severe droughts ~1100 years ago, which allegedly drove a population replacement in central Mexico by Aridoamerican peoples. In this study, we present shotgun genome-wide data from 12 individuals and 27 mitochondrial genomes from eight pre-Hispanic archaeological sites across Mexico, including two at the shifting border of Aridoamerica and Mesoamerica. We find population continuity that spans the climate change episode and a broad preservation of the genetic structure across present-day Mexico for the past 2300 years. Lastly, we identify a contribution to pre-Hispanic populations of northern and central Mexico from two ancient unsampled "ghost" populations.
Keyphrases
  • genome wide
  • climate change
  • african american
  • oxidative stress
  • machine learning
  • early onset
  • deep learning