Use of Anakinra to Prevent Mechanical Ventilation in Severe COVID-19: A Case Series.

Iris Y Navarro-Millán Sebastian Eduardo SattuiAmit LakhanpalDiane ZisaCaroline H Siegel Mary K Crow

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

Our data suggest that anakinra could be beneficial in treating COVID-19 patients with evidence of cytokine storm syndrome when initiated early after onset of acute hypoxemic respiratory failure. Our patient selection and treatment approach should be considered for investigation in a clinical trial to determine the safety and efficacy of anakinra in treating patients with COVID-19 and symptoms of cytokine storm syndrome.

Keyphrases

respiratory failure
mechanical ventilation
coronavirus disease
sars cov
acute respiratory distress syndrome
case report
extracorporeal membrane oxygenation
clinical trial
intensive care unit
early onset
randomized controlled trial
respiratory syndrome coronavirus
phase ii
sleep quality
data analysis