Modulations of probiotics on gut microbiota in a 5-fluorouracil-induced mouse model of mucositis.

Chun-Yan YeungJen-Shiu Chiang ChiauMei-Lein ChengWai-Tao ChanSzu-Wen ChangYuan-Hao ChangChuen-Bin JiangHung-Chang Lee

Published in: Journal of gastroenterology and hepatology (2019)

Gut microbiota of mice undergoing chemotherapy exhibited a distinct disruption in bacterial composition. Probiotic did modulate the abundance and diversity of gut microbiota. This is the first study to analyze the effects and safety of Lactobacillus strains on 5-FU-induced mucositis systematically and assess changes in the intestinal microbiota after probiotic intervention.

Keyphrases

mouse model
high glucose
diabetic rats
radiation induced
randomized controlled trial
escherichia coli
drug induced
chemotherapy induced
type diabetes
endothelial cells
radiation therapy
locally advanced
skeletal muscle
antibiotic resistance genes
high fat diet induced
microbial community