Efficacy and Safety of Denosumab vs Zoledronic Acid in OI Adults: A Prospective, Open-Label, Randomized Study.

Xiaoyun LinJing HuBingna ZhouXiaojie WangQian Zhang Yan Jiang Ou WangWeibo XiaXiaoping XingMei Li

Published in: The Journal of clinical endocrinology and metabolism (2024)

Denosumab effectively increases aBMD in adults with OI, with similar efficacy to zoledronic acid. Long-term and large-sample studies are needed to confirm the antifracture efficacy and safety of denosumab in adult patients with OI.

Keyphrases

bone mineral density
giant cell
open label
postmenopausal women
body composition
randomized controlled trial
rectal cancer
locally advanced