Small Animal Models of Respiratory Viral Infection Related to Asthma.
Mingyuan HanCharu RajputTomoko IshikawaCaitlin R JarmanJulie LeeMarc B HershensonPublished in: Viruses (2018)
Respiratory viral infections are strongly associated with asthma exacerbations. Rhinovirus is most frequently-detected pathogen; followed by respiratory syncytial virus; metapneumovirus; parainfluenza virus; enterovirus and coronavirus. In addition; viral infection; in combination with genetics; allergen exposure; microbiome and other pathogens; may play a role in asthma development. In particular; asthma development has been linked to wheezing-associated respiratory viral infections in early life. To understand underlying mechanisms of viral-induced airways disease; investigators have studied respiratory viral infections in small animals. This report reviews animal models of human respiratory viral infection employing mice; rats; guinea pigs; hamsters and ferrets. Investigators have modeled asthma exacerbations by infecting mice with allergic airways disease. Asthma development has been modeled by administration of virus to immature animals. Small animal models of respiratory viral infection will identify cell and molecular targets for the treatment of asthma.
Keyphrases
- chronic obstructive pulmonary disease
- lung function
- allergic rhinitis
- cystic fibrosis
- sars cov
- respiratory syncytial virus
- early life
- endothelial cells
- randomized controlled trial
- respiratory tract
- adipose tissue
- type diabetes
- mesenchymal stem cells
- oxidative stress
- high fat diet induced
- cell therapy
- smoking cessation
- drug induced
- antimicrobial resistance
- replacement therapy