Genome-wide DNA methylome analysis identifies methylation signatures associated with survival and drug resistance of ovarian cancers.

David Wai ChanWai-Yip LamFushun ChenMingo M H YungYau-Sang ChanWai-Sun ChanFangfang HeStephanie S LiuKaren K L ChanBenjamin LiHextan Y S Ngan

Published in: Clinical epigenetics (2021)

This study demonstrates the significant association of global hypermethylation with poor prognosis and drug resistance in high-grade EOC and highlights the potential of demethylating agents in cancer treatment.

Keyphrases

genome wide
poor prognosis
high grade
dna methylation
long non coding rna
copy number
gene expression
circulating tumor
free survival
young adults
data analysis