Spatial Metabolomics Identifies LPC(18:0) and LPA(18:1) in Advanced Atheroma With Translation to Plasma for Cardiovascular Risk Estimation.

Jianhua CaoMarta Martin-Lorenzo Kim van Kuijk Elias B Wieland Marion J J Gijbels Britt S R ClaesAngeles HerederoGonzalo Aldámiz Ron M A Heeren Pieter G Goossens Judith C Sluimer Benjamin Balluff Gloria Álvarez-Llamas

Published in: Arteriosclerosis, thrombosis, and vascular biology (2024)

An altered phospholipid metabolism occurs in atherosclerosis, affecting both the aorta and the adjacent heart tissue. Plaque-progression lipids LPC(18:0) and LPA(18:1), as identified by MSI on tissue, reflect cardiovascular risk in human plasma.

Keyphrases

fatty acid
cardiovascular disease
mass spectrometry
heart failure
genome wide
coronary artery disease
aortic valve
pulmonary artery
atrial fibrillation
type diabetes
gene expression
coronary artery
pulmonary arterial hypertension