miR-602 Mediates the RASSF1A/JNK Pathway, Thereby Promoting Postoperative Recurrence in Nude Mice with Liver Cancer.

Cheng ZhouYajing Huang Yongxu ChenYingjie XieHuihong WenWei TanChangjun Wang

Published in: OncoTargets and therapy (2020)

MiR-602 might inhibit the JNK signaling pathway by inhibiting the expression of RASSF1A, thereby promoting recurrence of liver cancer after surgery. The low expression levels of miR-602 in liver cancer tissues were closely related to postoperative recurrence; they could be used as a marker to judge the prognosis of patients with liver cancer.

Keyphrases

signaling pathway
long non coding rna
poor prognosis
cell proliferation
long noncoding rna
pi k akt
free survival
patients undergoing
induced apoptosis
cell death
epithelial mesenchymal transition
gene expression
metabolic syndrome
endoplasmic reticulum stress