Therapeutic Escape in Gαq-mutant Uveal Melanoma: It's a FAK.

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Through a synthetic lethal screen, ERK activation was found to mediate resistance to FAK inhibition in GNAQ-mutant uveal melanoma. With PLCB-PKC-ERK and Trio-FAK-Yap representing compensatory effectors of mutant Gαq signaling, combined inhibition of both pathways may be a promising therapeutic strategy in metastatic uveal melanoma.See related article by Paradis et al., p. 3190.

Keyphrases

signaling pathway
wild type
skin cancer
cell migration
cell proliferation
squamous cell carcinoma
pi k akt
small cell lung cancer
high throughput
basal cell carcinoma