Performance of a high-temperature proton exchange membrane fuel cell (HT-PEMFC) and the influence of different parameters on HT-PEMFC is analyzed in this study. Firstly, mathematical expression for energy efficiency, power density, exergy destruction and exergetic performance coefficient ( EPC ) are derived. Then, the relationship between the dimensionless power density, exergy destruction rate, exergetic performance coefficient ( EPC ) and energy efficiency is compared. Furthermore, the effect of flow rate, doping level, inlet pressure and film thickness are considered to evaluate the performance of HT-PEMFC. Results show that EPC not only considers exergetic loss rate to minimize exergetic loss, but also considers the power density of HT-PEMFC to maximize its power density and improve its efficiency, so EPC represents a better performance criterion. In addition, increasing inlet pressure and doping level can improve EPC and energy efficiency, respectively.