The Role of Thymoquinone in Inflammatory Response in Chronic Diseases.
Yan LiuLei HuangMi-Yeon KimYoung-Jin SonPublished in: International journal of molecular sciences (2022)
Anti-inflammatory therapies have been shown to be effective in the prevention of various cardiovascular diseases, tumors, and cancer complications. Thymoquinone (TQ), the main active constituent of Nigella sativa , has shown promising therapeutic properties in many in vivo and in vitro models. However, TQ has poor bioavailability and is hydrophobic, prohibiting clinical trials with TQ alone. Studies have explored the combination of TQ with biological nanomaterials to improve its bioavailability. The TQ nanoparticle formulation shows better bioavailability than free TQ, and these formulations are ready for clinical trials to determine their potential as therapeutic agents. In this paper, we review current knowledge about the interaction between TQ and the inflammatory response and summarize the research prospects in Korea and abroad. We discuss the different biological activities of TQ and various combination therapies of TQ and nanomaterials in clinical trials.
Keyphrases
- clinical trial
- inflammatory response
- healthcare
- anti inflammatory
- lipopolysaccharide induced
- phase ii
- squamous cell carcinoma
- metabolic syndrome
- type diabetes
- drug delivery
- lps induced
- randomized controlled trial
- risk factors
- climate change
- open label
- immune response
- squamous cell
- current status
- lymph node metastasis
- cardiovascular risk factors
- case control