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Transcript Profiles of Microglia/Macrophage Cells at the Borders of Chronic Active and Subpial Gray Matter Lesions in Multiple Sclerosis.

Anthony ChomykRikki KucinskiJihye KimEmilie ChristieKaitlyn CyncynatusZachary GossmanZhihong ChenBrian RichardsonMark CameronTim TurnerRanjan DuttaBruce D Trapp
Published in: Annals of neurology (2024)
We propose that the mechanisms of demyelination and dynamics of lesion expansion are responsible for differential transcript expression in WM lines and GM lines, and posit that increased expression of the Fc epsilon receptor, spleen tyrosine kinase, and Bruton's tyrosine kinase, play a key role in regulating microglia/macrophage function at the border of chronic active white matter lesions. ANN NEUROL 2024;95:907-916.
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