Natriuretic Effect of Two Weeks of Dapagliflozin Treatment in Patients With Type 2 Diabetes and Preserved Kidney Function During Standardized Sodium Intake: Results of the DAPASALT Trial.
Rosalie A ScholtesMarcel H A MuskietMichiel J B van BaarAnne C HespPeter J GreasleyCecilia KarlssonAnn HammarstedtNiki AryaDaniël H van RaalteHiddo J Lambers HeerspinkPublished in: Diabetes care (2020)
During standardized sodium intake, dapagliflozin reduced blood pressure without clear changes in urinary sodium excretion, suggesting that factors other than natriuresis and volume changes may contribute to the blood pressure-lowering effects.