A Canadian Study of Cisplatin Metabolomics and Nephrotoxicity (ACCENT): A Clinical Research Protocol.
Anshika JainRyan HuangJasmine LeeNatasha JawaYong Jin LimMike GuronSharon AbishPaul C BoutrosMichael BrudnoBruce CarletonGeoffrey D E CuvelierLakshman GunaratnamCheryl HoKhosrow AdeliSara KuruvillaGiles LajoieGeoffrey LiuPaul C NathanShahrad Rod RassekhMichael RiederSushrut S WaikarStephen A WelchMatthew A WeirEric WinquistDavid S WishartAlexandra P ZorziTom Blydt-HansenMichael ZappitelliBradley UrquhartPublished in: Canadian journal of kidney health and disease (2021)
ACCENT is the largest study of children and adults treated with cisplatin and aims to reimagine the current model for AKI diagnoses using metabolomics. The identification of biomarkers predicting and detecting AKI in children and adults treated with cisplatin can greatly inform future clinical investigations and practices.