Pan-Trk immunohistochemistry is a sensitive and specific ancillary tool for diagnosing secretory carcinoma of the salivary gland and detecting ETV6-NTRK3 fusion.
Ronald A GhosseinMohamed R Haroon Al RasheedCristina R AntonescuDeepu AlexDenise FrosinaRonald GhosseinAchim A JungbluthNora KatabiPublished in: Histopathology (2019)
Nuclear pan-Trk IHC is highly specific for SC diagnosis, with a specificity approaching 100%, making it a useful and precise diagnostic tool for differentiating SC from its histological mimics. On the other hand, any pan-Trk staining (nuclear or cytoplasmic) is highly sensitive for SC, and can serve as an attractive, cheap, fast and accessible screening tool for selecting patients to undergo confirmative molecular testing for clinical trials using TRK inhibitors.
Keyphrases
- clinical trial
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- acute lymphoblastic leukemia
- peritoneal dialysis
- randomized controlled trial
- magnetic resonance imaging
- high resolution
- patient reported
- fluorescent probe
- living cells
- double blind
- simultaneous determination