Early-Onset Pancreas Cancer: Clinical Descriptors, Genomics, and Outcomes.
Anna M VargheseIsha SinghRitu Raj SinghSiddharth KunteJoanne F ChouMarinela CapanuWinston WongMaeve Aine LoweryZsofia K StadlerErin Salo-MullenLily V SaadatAlice C WeiMarsha ReyngoldOlca BasturkRyma BenayedDiana L MandelkerChristine A Iacobuzio-DonahueDavid P KelsenWungki ParkKenneth H YuEileen M O'ReillyPublished in: Journal of the National Cancer Institute (2022)
PGVs are present in a substantial minority of patients with EOPC. Actionable somatic alterations were identified frequently in EOPC, enriched in the RAS wild-type subgroup. These observations underpin the recent guidelines for universal germline testing and somatic profiling in pancreatic ductal adenocarcinoma.