Low Levels of SPARC are Associated with Tumor Progression and Poor Prognosis in Human Endometrial Carcinoma.
Ling WangWei WangYangchun XuQiang WangPublished in: OncoTargets and therapy (2020)
The low expression of SPARC was detected in EC tissues and cells, which was positively correlated with the poor prognosis of EC patients. SPARC acted as a tumor suppressor gene that hindered EC progression, which proposed a new therapeutic strategy for EC treatment.
Keyphrases
- poor prognosis
- long non coding rna
- end stage renal disease
- induced apoptosis
- endothelial cells
- ejection fraction
- newly diagnosed
- chronic kidney disease
- gene expression
- prognostic factors
- peritoneal dialysis
- cell cycle arrest
- genome wide
- copy number
- cell death
- dna methylation
- endoplasmic reticulum stress
- smoking cessation
- replacement therapy