Zinc and COVID-19: Basis of Current Clinical Trials.
Amit PalRosanna SquittiMario PicozzaAnil PawarMauro RongiolettiAtanu Kumar DuttaSibasish SahooKalyan GoswamiPraveen SharmaRajendra PrasadPublished in: Biological trace element research (2020)
Coronavirus disease-2019 (COVID-19) pandemic continues to threaten patients, societies, and economic and healthcare systems around the world. Like many other diseases, the host immune system determines the progress of COVID-19 and fatality. Modulation of inflammatory response and cytokine production using immunonutrition is a novel concept that has been applied to other diseases as well. Zinc, one of the anti-inflammatory and antioxidant micronutrient found in food with well-established role in immunity, is currently being used in some clinical trials against COVID-19. This review integrates the contemporary studies of role of zinc in antiviral immunity along with discussing its potential role against COVID-19, and ongoing COVID-19 clinical trials using zinc.
Keyphrases
- coronavirus disease
- clinical trial
- sars cov
- inflammatory response
- healthcare
- respiratory syndrome coronavirus
- anti inflammatory
- end stage renal disease
- oxidative stress
- oxide nanoparticles
- chronic kidney disease
- randomized controlled trial
- peritoneal dialysis
- risk assessment
- study protocol
- prognostic factors
- patient reported outcomes