Metabolic changes induced by DNA damage in Ramos cells: exploring the role of mTORC1 complex.
Marcos Castro-GuardaYennyfer ArancibiaCarina ChipónChristofer MatamalaPaola OyarzoGabriela VargasAlejandro ReyesMónica SalasFrancisco J MoreraAngara ZambranoPublished in: FEBS open bio (2022)
DNA damage induces the activation of many different signals associated with repair or cell death, but it is also connected with physiological events, such as adult neurogenesis and B-cell differentiation. DNA damage induces different signaling pathways, some of them linked to important metabolic changes. The mTORC1 pathway has a central role in the regulation of growth processes and cell division in response to environmental changes and also controls protein synthesis, lipid biogenesis, nucleotide synthesis, and expression of glycolytic genes. Here, we report that double-strand breaks induced with etoposide affect the expression of genes encoding different enzymes associated with specific metabolic pathways in Ramos cells. We also analyzed the role of mTOR signaling, demonstrating that double-strand breaks induce downregulation of mTOR signaling. Specific inhibition of mTORC1 using rapamycin also induced changes in the expression of metabolic genes. Finally, we demonstrated that DNA damage and rapamycin can regulate glucose uptake. In summary, our findings show that etoposide and rapamycin affect the expression of metabolic genes as well as apoptotic and proliferation markers in Ramos cells, increasing our understanding of cancer metabolism.
Keyphrases
- dna damage
- induced apoptosis
- cell death
- cell cycle arrest
- poor prognosis
- oxidative stress
- signaling pathway
- dna repair
- genome wide
- cell proliferation
- endoplasmic reticulum stress
- pi k akt
- long non coding rna
- stem cells
- squamous cell carcinoma
- diabetic rats
- adipose tissue
- bioinformatics analysis
- risk assessment
- dna methylation
- blood pressure
- metabolic syndrome
- young adults
- epithelial mesenchymal transition
- human health
- papillary thyroid
- drug induced
- anti inflammatory