RNA interference or small molecule inhibition of Runx1 in the border zone prevents cardiac contractile dysfunction following myocardial infarction.

Tamara P MartinEilidh A MacDonaldAshley BradleyHolly WatsonPriyanka SaxenaEva A Rog-ZielinskaAnmar RaheemSimon FisherAli Ali Mohamed ElbassioniOhood AlmuzainiCatriona BoothMorna CampbellAlex RiddellPawel HerzykKaren BlythColin NixonLorena Zentilin Colin BerryThomas BraunMauro GiaccaMartin W McBrideStuart A NicklinEwan R CameronChristopher M Loughrey

Published in: Cardiovascular research (2023)

Our results confirm the translational potential of RUNX1 as a novel therapeutic target in myocardial infarction, with wider opportunities for use across a range of cardiac diseases where RUNX1 drives adverse cardiac remodelling.

Keyphrases

left ventricular
small molecule
transcription factor
heart failure
skeletal muscle
emergency department
adverse drug