Dicer1 Deficiency in the Idiopathic Pulmonary Fibrosis Fibroblastic Focus Promotes Fibrosis by Suppressing MicroRNA Biogenesis.

Jeremy HerreraDaniel J BeisangMark PetersonColleen ForsterAdam GilbertsenAlexey BenyumovKaren SmithChristopher E KorenczukVictor H BarocasKacey GuentherRyan HiteLin ZhangCraig A HenkePeter B Bitterman

Published in: American journal of respiratory and critical care medicine (2019)

Our data identify suppression of fibroblast Dicer1 expression in the myofibroblast-rich IPF fibroblastic focus core as a central step in the mechanism by which the ECM sustains fibrosis progression in IPF.

Keyphrases

idiopathic pulmonary fibrosis
interstitial lung disease
poor prognosis
electronic health record
liver fibrosis
big data
binding protein
long non coding rna
rheumatoid arthritis
artificial intelligence
wound healing
deep learning