Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018-2022.
Sunmin WooLewis MarquezWilliam J CrandallCaitlin J RisenerCassandra Leah QuavePublished in: Natural product reports (2023)
Covering: 2018 to 2022Antimicrobial resistance (AMR) poses a significant global health threat. There is a rising demand for innovative drug scaffolds and new targets to combat multidrug-resistant bacteria. Before the advent of antibiotics, infections were treated with plants chosen from traditional medicine practices. Of Earth's 374 000 plant species, approximately 9% have been used medicinally, but most species remain to be investigated. This review illuminates discoveries of antimicrobial natural products from plants covering 2018 to 2022. It highlights plant-derived natural products with antibacterial, antivirulence, and antibiofilm activity documented in lab studies. Additionally, this review examines the development of novel derivatives from well-studied parent natural products, as natural product derivatives have often served as scaffolds for anti-infective agents.
Keyphrases
- antimicrobial resistance
- global health
- staphylococcus aureus
- multidrug resistant
- public health
- gram negative
- tissue engineering
- small molecule
- primary care
- drug resistant
- acinetobacter baumannii
- emergency department
- pseudomonas aeruginosa
- newly diagnosed
- anti inflammatory
- atomic force microscopy
- wound healing
- genetic diversity