Augmenter of liver regeneration knockout aggravates tubular ferroptosis and macrophage activation by regulating carnitine palmitoyltransferase-1A-induced lipid metabolism in diabetic nephropathy.

Yuanyuan Zhang Zheng ZhangLili HuangChunxia WangPengfei YangLing ZhangXiao-Hui Liao

Published in: Acta physiologica (Oxford, England) (2024)

Taken together, our findings revealed a crucial protective role of ALR in ferroptosis induction and macrophage activation in DN and identified it as an alternative diagnostic marker and therapeutic target for DN.

Keyphrases

diabetic nephropathy
cell death
high glucose
adipose tissue
stem cells
diabetic rats
endothelial cells
fatty acid
oxidative stress