ERK and Akt exhibit distinct signaling responses following stimulation by pro-angiogenic factors.

Published in: Cell communication and signaling : CCS (2020)

Overall, the model predicts the combination effects of FGF and VEGF stimulation on ERK and Akt quantitatively and provides a framework to mechanistically explain experimental results and guide experimental design. Thus, this model can be utilized to study the effects of pro- and anti-angiogenic therapies that particularly target ERK and/or Akt activation upon stimulation with FGF and VEGF. Video Abstract.

Keyphrases

signaling pathway
cell proliferation
pi k akt
vascular endothelial growth factor
endothelial cells
anti inflammatory