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Periocular Sebaceous Carcinoma: A Case Audit from the National Specialist Ophthalmic Pathology Service in Liverpool from 2009 to 2022 to Assess the Diagnostic Utility of PRAME Expression.

Amizatul Aini SallehYamini KrishnaSarah E Coupland
Published in: Ocular oncology and pathology (2023)
Most PSCs are moderate-to-poorly differentiated. Although PRAME is expressed in normal sebaceous units, it appears less useful as diagnostic marker for PSC, especially in poorly differentiated tumors. In difficult cases, panels of IHC studies (adipophilin, Ber-EP4, and EMA) achieve a definitive diagnosis.
Keyphrases
  • poor prognosis
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  • squamous cell carcinoma
  • binding protein
  • case control