A haunted beast: Targeting STAT5BN642H in T-Cell Neoplasia.

Ha Thi Thanh PhamMarkus HengstschlägerRichard Moriggl

Published in: Molecular & cellular oncology (2018)

The somatic hot spot mutation STAT5BN642H was found in many T cell leukemia/lymphoma patients. We generated and analyzed a transgenic mouse model with hematopoietic STAT5BN642H expression that caused aggressive T-cell leukemia/lymphomas. Herein, we discuss the scientific merit of our model and its relevance for pre-clinical studies.

Keyphrases

bone marrow
mouse model
end stage renal disease
cell proliferation
acute myeloid leukemia
ejection fraction
chronic kidney disease
newly diagnosed
poor prognosis
high grade
peritoneal dialysis
cancer therapy
gene expression
dna methylation
binding protein
copy number
drug delivery
long non coding rna