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Do proton pump inhibitors increase the risk of dementia? A systematic review, meta-analysis and bias analysis.

Nayeon AhnMichael NoldeEvamaria KrauseFlorian GüntnerAlexander GünterMartin TauscherRoman GerlachChrista MeisingerJakob LinseisenSebastian-Edgar BaumeisterIna-Maria Rückert-Eheberg
Published in: British journal of clinical pharmacology (2022)
This meta-analysis provided no clear evidence for an association between PPI intake and the risk of dementia. Due to discrepancies in sensitivity analyses, however, some risk of dementia by PPI use cannot be ruled out. Since an unequivocal conclusion is still pending, further research is warranted.
Keyphrases
  • systematic review
  • mild cognitive impairment
  • cognitive impairment
  • meta analyses
  • protein protein
  • case control
  • randomized controlled trial
  • small molecule