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The increasing importance of histologic grading in tailoring adjuvant systemic therapy in 30,843 breast cancer patients.

C van DooijeweertI O BaasI A G DeckersS SieslingPaul J van DiestE van der Wall
Published in: Breast cancer research and treatment (2021)
In the largest study published so far we illustrate the increasing importance of histologic grade in tailoring adjuvant systemic breast cancer therapy. Next to playing a key-role in aCT-indication and de-escalation, the role of grading has expanded to the indication for aET. Optimizing histologic grading by pathologists is urgently needed to diminish the risk of worse patient outcome due to non-optimal treatment.
Keyphrases
  • cancer therapy
  • early stage
  • drug delivery
  • case report
  • randomized controlled trial
  • systematic review
  • stem cells
  • combination therapy
  • meta analyses