Melatonin receptor 1A, but not 1B, knockout decreases biliary damage and liver fibrosis during cholestatic liver injury.
Nan WuCarpino GuidoLudovica CeciLeonardo BaiocchiHeather FrancisLindsey KennedyTianhao ZhouLixian ChenKeisaku SatoKonstantina KyritsiVik MeadowsBurcin EkserAntonio FranchittoRomina MancinelliPaolo OnoriEugenio GaudioShannon GlaserGianfranco AlpiniPublished in: Hepatology (Baltimore, Md.) (2021)
Melatonin ameliorates liver phenotypes through MT1, whereas down-regulation of MT2 promotes liver damage through GPR50/TGFβR1 activation. Blocking GPR50/TGFβR1 binding through modulation of melatonin signaling may be a therapeutic approach for PSC.