Metformin Affects Gut Microbiome Composition and Function and Circulating Short-Chain Fatty Acids: A Randomized Trial.
Noel T MuellerMoira K DifferdingMingyu ZhangNisa M MaruthurStephen P JuraschekEdgar R MillerLawrence J AppelHsin-Chieh YehPublished in: Diabetes care (2021)
Metformin, but not behavioral weight loss, impacted gut microbiota composition at 6 months and 12 months. Both metformin and behavioral weight loss altered circulating SCFAs at 6 months, including increasing acetate, which correlated with lower fasting insulin. Future research is needed to elucidate whether the gut microboime mediates or modifies metformin's health effects.