Intensive Serum Urate Lowering With Oral Urate-Lowering Therapy for Erosive Gout: A Randomized Double-Blind Controlled Trial.

Nicola DalbethAnthony J DoyleKaren BillingtonGreg D GamblePaul TanKieran LattoThrishila Parshu RamRavi NarangRachel MurdochDavid BursillBorislav MihovLisa K StampAnne Horne

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

Compared to a serum urate target of <0.30 mmoles/liter, more intensive serum urate lowering is difficult to achieve with an oral urate-lowering therapy. Intensive serum urate lowering leads to a high medication burden and does not improve bone erosion scores in patients with erosive gout.

Keyphrases

double blind
healthcare
study protocol
stem cells
emergency department
metabolic syndrome
randomized controlled trial
bone mineral density
bone marrow
postmenopausal women
soft tissue
cell therapy
phase ii
drug induced