The Expression of Adipose Tissue-Derived Cardiotrophin-1 in Humans with Obesity.
Jacqueline StephensEric RavussinUrsula A WhitePublished in: Biology (2019)
Cardiotrophin-1 (CT-1) is a gp130 cytokine that was previously characterized for its effects on cardiomyocytes and identified as a marker of heart failure. More recent studies reported elevated circulating levels of CT-1 in humans with obesity and metabolic syndrome (MetS). However, a subsequent rodent study implicated CT-1 as a potential therapeutic target for obesity and MetS. Adipose tissue (AT) is broadly acknowledged as an endocrine organ and is a substantial source of CT-1. However, no study has examined the expression of adipose-derived CT-1 in humans. We present the first analysis of CT-1 mRNA expression in subcutaneous AT and its association with clinical variables in 22 women with obesity and 15 men who were 40% overfed for 8-weeks. We observed that CT-1 expression was higher in the subcutaneous abdominal (scABD) than the femoral (scFEM) depot. Importantly, we reveal that scFEM but not scABD, CT-1 expression was negatively associated with visceral adiposity and intrahepatic lipid, while positively correlated with insulin sensitivity in obese women. Also, men with higher CT-1 levels at baseline had less of a decline in insulin sensitivity in response to overfeeding. Our data provide new knowledge on the regulation of adipose-derived CT-1 in obesity and during weight gain in response to overfeeding in humans and suggest that CT-1 may play a protective role in obesity and related disorders.
Keyphrases
- metabolic syndrome
- insulin resistance
- image quality
- weight gain
- dual energy
- computed tomography
- contrast enhanced
- adipose tissue
- weight loss
- type diabetes
- heart failure
- poor prognosis
- positron emission tomography
- high fat diet induced
- magnetic resonance imaging
- body mass index
- bariatric surgery
- high fat diet
- magnetic resonance
- cardiovascular disease
- physical activity
- pregnant women
- climate change
- long non coding rna
- electronic health record
- atrial fibrillation
- cardiovascular risk factors
- acute heart failure
- artificial intelligence
- breast cancer risk
- gestational age