Beta-Hydroxybutyric Acid Inhibits Renal Tubular Reabsorption via the AKT/DAB2/Megalin Signalling Pathway.

Minxia Zuo Cheng Meng Qian Song Zhongai Gao Xiao Cui Jing Yu Wang Yongmei Li Xiaochen Li Chun Yan Shan Juhong Yang Bao Cheng Chang

Published in: Journal of diabetes research (2022)

Patients with diabetic ketosis may suffer from glomerular and tubular injuries that recover after ketosis control. High concentrations of BOHB downregulate megalin expression by inhibiting the AKT/DAB2/megalin signalling pathway and albumin endocytosis in proximal renal tubules.

Keyphrases

signaling pathway
high glucose
cell proliferation
poor prognosis
type diabetes
endothelial cells
binding protein
diabetic nephropathy